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Crystal structure of the DGC PleD that reveals the fold of the GGDEF domain and a new allosteric c-di-GMP-binding site that is involved in product inhibition

PMID 10730193

Both are nearly identical and contain a cobalt ion surrounded by a corrin ring

Post-operatively the animals were housed individually in an American Accreditation for Laboratory Animal the water maze consisted of a circular tank painted black (diameter: 1.6 m

Giving it one last go

In general, three different groups of agents were described in the past: (i) mAbs, either targeting the ligand HGF or the receptor Met, (ii) tyrosine kinase inhibitors, targeting the tyrosine kinase domain of Met (and mostly also the TK domain of other RTKs), (iii) a truncated, soluble Met receptor serving as decoy for HGF (44) and the competitive HGF antagonist NK4 (18)