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4 The role of Sirts in PD Sirtuins (Sirts) are proteins that belong to the nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases family (Histone Deacetylase or HDAC)

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Aging is a complex, multifactorial process, but circadian rhythm disruption, sleep deterioration, oxidative stress, and chronic inflammation are among its central features