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Metabolic regulation of homologous recombination repair by Mre11 lactylation

[DOI] [PubMed] [Google Scholar] 31.Guo G, Yan-Sanders Y, Lyn-Cook BD, et al

Furthermore, altered expression of DNA repair or immune-inflammatory pathways, such as innate immunity genes, including MyD88 , TLR4 and TLR5 , have been associated with changes in the microbiome composition (48)

doi: 10.3389/fimmu.2019.00996 16 CarpenterSMLuLL

Targeted silencing or complete global knockout of KDM3A expression significantly mitigated oxidative stress, suppressed NF-B/P65 activation, reduced apoptosis and fibrosis, and improved cardiac function, which indicates the therapeutic potential of HDMi in diabetic cardiovascular injury [227]
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Taken together, there is growing evidence pointing to a possible interaction between CAT polymorphisms and relevant nutrients, indicating that an individuals genome should be taken into consideration when planning nutrient intake and that interaction between dietary components and the personal genome is a significant factor in health and disease
