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The same methodology previously used for dietary antioxidant studies can be applied to inhaled antioxidants, although inter-subject differences in inhalation technique, breathing patterns, and variability in nebulizer output present unique challenges to aerosol treatment

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Furthermore, this process is associated with an increase in ROS production, down-regulation of anti-apoptotic proteins such as Bcl-2, and up-regulation of pro-apoptotic proteins including p53 and p21 (58)

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Our prior pharmacokinetic studies revealed rapid metabolism of BPC157 into small peptide fragments, ultimately yielding single amino acid residues (predominantly proline) in plasma, urine, and feces [11]

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