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Furthermore, HSP70 could be considered a potential marker to evaluate disease activity.3,5,6 On the other hand, MxA protein (human mixovirus resistance protein 1), inducible by IFN-, shows strong expression in active perilesional vitiligo skin, suggesting a contributing effect of IFN- in disease progression.7 Similarly, S100B is another DAMP released by damaged melanocytes, whose levels are increased in active vitiligo and can stimulate inflammatory responses.8 Also, high-mobility group box 1 (HMGB1) proteins can induce the production of chemokine ligands, such as CXCL1 or IL-8 by keratinocytes, acting in the recruitment of immune cells.9 Calreticulin (CRT) is another of the most studied molecules in vitiligo, as it induces melanocyte apoptosis and the release of membrane degradation products important for immunogenicity.10 Melanocyte adhesion deficiency Several research groups have demonstrated that melanocytes in vitiligo exhibit reduced adhesive properties

Mol Psychiatry 26 , 26162625 (2021)

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The formula contains LIPO GLUTA NIAC CEN 12.5% , featuring Glutathione 1,000ppm , Niacinamide 1,000ppm , and Centella Asiatica Extract 12.3% , along with the Centella 3X Complex made from Madecassic Acid, Asiaticoside, and Asiatic Acid to calm and protect sensitive skin

New insights on the combined removal of antibiotics and ARGs in urban wastewater through the use of two configurations of vertical subsurface flow constructed wetlands

Recent research has also evaluated PRP as a potential treatment for joint disease