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These medications have been studied in large human clinical trials, reviewed by regulators, prescribed by healthcare professionals, and monitored after approval

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3 , 4 For example, although limited, a 1-year follow-up study reported an increase in levels of factors IX and XII and diminished levels antithrombin and protein C in gender-diverse and transgender individuals receiving estrogen

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There is preclinical and animal data along with methodologically flawed studies

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