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Of note, betulinic acid also reduced the levels of poly-ubiquitinated LIP, indicating that if favored the removal of ubiquitinated LIP via proteasome

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Larson RA

Furthermore, mechanistic insights suggest that KD may modulate tumor metabolism and immune responses, thereby contributing to a more therapeutically responsive tumor microenvironment

Cell 92 , 735745 (1998)

lipoatrophic diabetes, Wolfram syndrome, Down syndrome, Klinefelter syndrome (XXY males), Turner syndrome, type 1 myotonic dystrophy, muscular dystrophy, Huntington disease, Friedreich ataxia, Prader-Willi syndrome, Werner syndrome, Cockayne syndrome, and others such as those indicated above