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In healthy controls, DNIC activation reduced pain scores, whereas this effect was absent in IBS patients, with distinct patterns of brain region activation observed between the two groups

[DOI] [PubMed] [Google Scholar] 340.Ziliotto S, et al

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It is a fat-soluble micronutrient synthesized by all human cells and tissues that can also be taken exogenously to mitigate ROS damage, as CoQ10 is able to reduce superoxide production in mitochondria 176,177