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Neuroscientist Neurol
12,14 This allows for a shift in macrophage activity from M1 (pro-inflammatory) to M2 (reparative)

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Neurodegenerative memory disorders: a potential role of environmental toxins

These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects

10.1016/j.devcel.2009.06.013 94 OnishiM.YamanoK.SatoM.MatsudaN.OkamotoK
