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Description
Novel prodrugs of monomethyl fumarate have achieved site-specific release at OS loci via BaeyerVilliger oxidation, minimizing systemic side effects while activating Nrf2 locally ( However, the therapeutic potential of Nrf2 activation is tempered by paradoxical risks

Proc Natl Acad Sci USA 104 : 1662116626

No mass shift induced by DEL7 was observed, which was consistent with a non-covalent binding mechanism of DEL7 to the 3CL protease

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