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Zhang and colleagues found that in db/db mice, the expression of HMGCS2 was significantly elevated in the kidneys, leading to enhanced production of ketone bodies, particularly BHB

doi: 10.1002/(SICI)1097-4547(19990715)57:2 3.0.CO;2-P 117

The lead candidate is currently in preclinical toxicology studies thatif successfulwill allow progress into clinical studies that have the potential to address life-threatening infections by the Gram-negative pathogens, and thus to resolve a considerable unmet medical need

The primary mechanical action relies on the physical presence of the needle tip, which mechanically disrupts the locked, dysfunctional motor endplates within the taut band of muscle

Whilst peptidic inhibitors have been developed to weaken the integrity of the shelterin complex or target its interactions with partners, the direct modulation of protein interactions within shelterin using small molecules has been largely unexplored 12,13