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Disruption of the redox equilibrium promotes oxidative damage and thus, the aggregation of proteins that lead to the loss of the transparency of the lens (29)

These studies demonstrated that maintaining cystine homeostasis within cells is essential for cell survival, as cystine deficiency causes ferroptosis, and excessive cystine accumulation leads to disulfidptosis

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In retinal ischemia models (induced by vessel ligation or elevated pressure), BPC-157 treatment increases retinal VEGF levels 2-3 fold within days promoting revascularization

These findings suggest that in the galactose-induced cataract model, oxidative stress induces ER stress, leading to EMT and apoptosis, which, in turn, results in cataracts (Fig

VIP Vasoactive Intestinal Peptide is a neuropeptide with regulatory effects across multiple systems