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Research has shown that also the insulin-like growth factor 1 (IGF-1) haplotype plays a critical role in determining size differences in dogs, with smaller breeds exhibiting lower levels of IGF-1, which may contribute to their increased longevity [67]

This work was also funded by the Italian Ministry for University and Research (MIUR), grant PRIN: rot

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suggest that chronic inflammation also activates molecules such as macrophages, which trigger cell death pathways in liver cells

doi: 10.1016/S0009-8981(99)00150-3

Attenuation of the IGF-1/AKT pathway in muscle satellite cells from CKD mice leads to reduced levels of myogenic markers, resulting in poor muscle regeneration, fibrosis, and the consequent muscle wasting.134 In hemodialysis patients, it has been recently demonstrated that the association between plasma IGF-1 and muscle strength is comparable to that of the myostatin, a well-known inhibitor of muscle growth, and both similarly predict mortality in this population.135 In this regard, the relationship between higher plasma IGF-1, muscle strength and survival could be expected