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[DOI] [PubMed] [Google Scholar] 65.Park W.K., Chang C.H., Chae J.E., Kim M.H., Cho Y.L., Ahn D.S

Ongoing trials (eg, TAME trial for Metformin, D+Q trials for aging-related diseases) will provide critical insights, but more diverse human studies are required.127 Bioavailability Challenge: In terms of translational application, bioavailability remains a significant challenge for many senolytic compounds, particularly plant-derived polyphenols such as fisetin and quercetin, which exhibit poor oral absorption, rapid metabolism, and low systemic retention

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The findings of the study failed to show improvements in invasive disease-free survival or OS upon the addition of bevacizumab to chemotherapy in adjuvant settings in breast cancer patients with high-risk HER2-negative disease (Miller et al., 2018)

For instance, research conducted by Lis team revealed that Bacteroides is the predominant genus involved in polyamine biosynthesis
