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EF24, a notable derivative of curcumin, has been demonstrated to increase PTEN expression and subsequently inhibit the NF-B pathway (Table 1)

51, 74, 75, 76, 77, 78 The molecular mechanisms that underlie the cytotoxic potential of cytoplasmic CDDP are poorly understood, yet may involve: (i) the accumulation of reactive oxygen species (ROS) and nitric oxide (NO), which not only exacerbate CDDP genotoxicity but also exert direct cytotoxic effects by favoring the opening of the so-called permeability transition pore complex (PTPC)

The primary objective is to develop drugs with heightened selectivity and efficacy while minimizing off-target toxicity to healthy cells

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These powerful add-ons include glutathione, magnesium, NAD+, Taurine, Zinc, and MIC with carnitine

Thereafter, trypsin at 1:50 was poured for overnight digestion and that at 1:100 was introduced for additional 4 h of digestion, followed by peptide desalting using a C18 SPE column