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Together, these findings reveal that prostate cancer cells are exquisitely sensitive to metabolic perturbations that affect the balance between glucose and the pentose phosphate pathway and implicate PFKFB4 as a potential therapeutic target (Ros et al 2012)

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FIGURE 4 4 Discussion Air pollution has been considered as a worldwide public health concern and has drawn more attention recently ( The PM2.5 concentration in Shijiazhuang is extremely high, with annual average PM2.5 concentrations as high as 138.8 g/m 3 in 20142016 ( 3 and SO 4 2 ) in the water-soluble fraction ( According to a World Health Organization survey in 2020, 38.9 million children under the age of five were overweight worldwide, and the number of adolescents and adults population suffering from obesity reached 340 million and 650 million, respectively ( It is well known that the development of overweight and obesity is accompanied by excessive storage of lipids in adipose tissue ( The crosstalk between the liver and adipose tissue is pivotal for regulating lipid metabolism

However, misuse or high dosages may lead to adverse effects