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Neurological signs and symptoms include delayed development and developmental regression, muscle weakness (hypotonia), seizures, and abnormal movements

Briefly, -2 agonists specifically bind to and activate G-protein-coupled receptors that in turn trigger the stimulation/activation of a series of enzymes

Severe and chronic unbalance between ROS and antioxidant systems would lead to oxidative damage on proteins, lipids and DNA with drastic irreversible effects

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Overcoming these challenges requires the exploration of smaller CD38-binding molecules, with a particular focus on single domain antibodies (sdAbs) derived from the heavy chain antibodies of Camelidae species [87]