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They are not intended to represent instructions, recommendations, or guidance for personal use

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Free radicals are byproducts of normal bodily processes and external factors like pollution, stress, and unhealthy lifestyles

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For HIF transcription factors, this occurs by hydroxylation at conserved proline residues by prolyl hydroxylases under normoxia, allowing their recognition and ubiquitination by the VHL E3 ubiquitin ligase, which targets HIFs for proteasomal degradation

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A., Harper, J

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Cochrane Database of Systematic Reviews 2004, Issue 3

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