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Pregnant or breastfeeding women, and people with certain medical conditions (like uncontrolled asthma or kidney issues) should avoid treatment

Initially, the pathogenesis of NASH was explained by the 2-hit hypothesis, where the first hit, hepatic triglyceride accumulation (steatosis), increases the livers susceptibility to injury from second hits, such as inflammatory cytokines, mitochondrial dysfunction, and oxidative stress [37,38]

Semaglutide activates GLP-1 receptors for appetite suppression, gastric emptying delay, and glucose homeostasis

Sandoval, D

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However, there is insufficient long-term safety data