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In most of the studies, patients with general histamine-associated symptoms were evaluated, but in the study of Yacoub et al

Renerve Plus Injection Composition Methylcobalamin (active form of vitamin-B): 1,000-g Vitamin B6 (Pyridoxine Hydrochloride) : 100 mg Vitamin B3 (Niacinamide/Nicotinamide) : 100 mg Thiamine Hydrochloride (Vitamin B1) : 100 mg DPanthenol (Provitamin B5) : typically around 50 mg Some formulations may also include trace amounts of folic acid, selenium, -lipoic acid, vitamin E, carotene, chromium, and zinc, depending on regional variations

They deliver the vitamin directly into the bloodstream for faster results

V.NaganoH.MayamaT.OhkuboS.et al (2010)

Further surface modification resulted in reduction in zeta potential to 10.26 mV due to replacement of citrate ion with GSH

Vitamin E has anti-inflammatory properties that can relieve irritated or inflamed skin