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A second RCT tested 4g/day low-molecular-weight collagen peptides for 12 weeks in osteoarthritis patients

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Withdrawal, which manifests as shutting oneself off, isolating, weakening, emotional reactions, or depressive states

Roughly 90% of compounds that work in animal studies fail in human trials

Elevated BSH activity causes an increase in secondary bile acids in the intestine, and some secondary bile acids, especially deoxycholic acid, can promote gallstone formation via enterohepatic circulation (Wang et al., 2020)