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Only a few studies showed increased cellular GSH levels [65,67]

A dose escalation study of trientine plus carboplatin and pegylated liposomal doxorubicin in women with a first relapse of epithelial ovarian, tubal, and peritoneal cancer within 12 months after platinum-based chemotherapy

Molecular and cellular insights into T cell exhaustion

(2024) 31:163049.e8

Similarly, inflamed tissues release specific chemicals (chemokines) that guide neutrophils along the concentration gradient 27,28,29

Based on studies of plants deficient in enzymes such as ascorbate peroxidase (APX) and catalase (CAT), accumulation of GSSG is quite closely related to the intracellular availability of H 2 O 2 (Rizhsky et al., 2002