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[DOI] [PMC free article] [PubMed] [Google Scholar] Meister A

[91] found that early-life fisetin administration enhanced glucose metabolism, cognitive function, and reduced SASP expression in male mice, indicating sex-dependent responses to preventive interventions

G.BondarevaE

Furthermore, oxidative stress activates the NF-B pathway to stimulate proinflammatory cytokine production 50,51

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Discussion The findings of this study show that MTX treatment causes oxidative tissue damage in the liver and kidney, as measured by increased LPO and decreased GSH levels, SOD and GST activities, whereas whey protein administration protects against this oxidative damage