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Description
mTOR: Mechanistic target of rapamycin

& Topal, J

It was one of the first enzymes of glucose metabolism to be identified, but, although Warburg did not know that, the clinical manifestations of what later became known as G6PD deficiency had been already described

HIV-1 Tat exposure induces a senescence-like phenotype in microglia with elevated senescence markers and pro-inflammatory cytokines [66, 67]

Similarly, a polymorphism in the ITGB3 geneencoding for Integrin B3was not correlated with the development of oxaliplatin-induced CIPN, although it appeared to be related to the severity of this symptom (Antonacopoulou et al., via the differential activation of the mitogen activated protein kinases MAPK3 and MAPK1 that are induced by these ITGB3 variants, and which may contribute to development of CIPN (Scuteri et al., 2009)
The propionyl CoA is converted in three enzymatic steps, one of which is one of only two reactions in Humans that required vitamin B 12 , to Succinyl CoA, an intermediate of the TCA cycle
