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As NAC may share common anti-inflammatory mechanisms with other multimodal analgesics like NSAIDs, a more specific multimodal combination or head-to-head comparison strategy may better elucidate NACs unique analgesic potential, particularly as NAC may be more tolerable for NSAID-intolerant patients with renal insufficiency

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In one study, pyrosequencing was employed to measure DNA methylation levels in blood, analyzing 46 cytosine-guanine sites across 21 genes (including NXN, ABCA7, and HOXA3) to evaluate its diagnostic accuracy for non-invasive detection of late-onset AD (70)