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You can find additional explanations in the later sections of the article that will enhance your understanding
doi: 10.1056/NEJMoa0903627 143 BermanJ

The utilization of GSH is consequential to its chemical structure

Its main job is helping protect cells from oxidative stress caused by unstable molecules known as free radicals
hence, this detoxification pathway consumes intracellular glutathione in an irreversible way [38]

doi: 10.20471/acc.2019.58.02.13