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Another advanced option is combining GHK-Cu with Platelet-Rich Plasma (PRP) therapy
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HMGB1 translocation from nucleus to the cytoplasm of renal tubular cells induces ferroptosis by binding ACSL4 after renal I/R injury, and inhibition the nuclear cytoplasmic translocation of HMGB1 could inhibit ferroptosis and renal I/R injury

Figure 3 The PKC- isoform is primarily responsible for the damage to the barrier and leakage by phosphorylating tight junction proteins and mediating their dysregulation

EY: Conceptualization, Investigation, Visualization, Writing original draft
