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Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

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These mutations are characterized by more severe iron accumulation and earlier onset of disease than Type 1 HH.6 Mutations in HAMP, the gene encoding hepcidin, result in Type 2 HH, a form of juvenile hemochromatosis

While glia-derived glutamine provides 5060% of a glutamate neurotransmitter, when the pathway is blocked with MeAIB, excitatory transmission abruptly decreases but rapidly recovers, consistent with endogenous neuronal sources of glutamate neurotransmitter (15)

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