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This symmetry likely reflects both the widespread distribution of melanocytes and the systemic nature of the compounds effects [26]

However, in another study asthma patients (ages 15-45) receiving oral choline supplementation (1500 mg b.i.d.) with inhaled steroids (Budesonide

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It is critical to note that although numerous (around 50) compounds have been investigated in randomized clinical trials, almost all of them failed to show efficacy except riluzole, the only approved drug so far (Mitsumoto et al., 2014)