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Importantly, non-thiol antioxidants typically exhibited limited or no efficacy, underscoring NACs distinctive thiol-based mechanism [86,88]

doi: 10.1212/01.wnl.0000225050.57553.6d

Owing to the selenoprotein hierarchy, GPx-1 is one of the selenoproteins most readily affected by selenium levels

Early case series and open-label studies support feasibility and biological plausibility, whereas randomized trials show mixed clinical signals, highlighting donor-dependent effects, protocol heterogeneity (preconditioning, route, dose/frequency), and the need for engraftment-aware endpoints [252,253,254,255]

long-term effects on NAD+ metabolism, liver function, and cardiovascular health are unknown

[DOI] [PubMed] [Google Scholar] 112.Mandhane S.D.S., Jani K., Sengupta P., Patel A., Bambal R., Ramanathan V., Zala Y., Dharmadhikari N., Rao C., Raghavan A., et al