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In vitro studies, preclinical studies, retrospective studies and randomized clinical trials performed in Europe and the USA were included

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Furthermore, the use of flavonoids as iron-chelating agents requires risk and benefit assessment and comparison with existing treatments

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In addition, glycolysis inhibitors (e.g., 2-deoxyglucose, 2-DG) disrupt glucose metabolism in highly glycolytic normal tissues, such as the brain (neurotoxicity) and heart (cardiotoxicity) [30]

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