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utilized male C57BL/6J mice to establish a liver fibrosis model, and the administration of pirfenidone indicated that it targets glutaredoxin-1 to suppress hematopoietic stem cell activation and liver fibrosis [57]

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The models unexpectedly show that lacking a functional NNT presents with less oxidative damage to the heart compared to mice with active NNT

doi: 10.1016/s0149-2918(03)90096-8

With regard to the long-term use of iron chelators in patients with chronic diseases, these patients may experience specific side effects, such as rash, nausea and dizziness, diarrhea, vomiting, hearing and vision loss, abdominal pain, and increasing risk of infection (Mobarra et al., 2016