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In Phase I/II combination study with irinotecan and cetuximab in selected patients with KRAS WT locally advanced or mCRC (NCT01075048), the addition of tivantinib did not improve PFS, the primary endpoint (Eng et al., 2016)

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But the most significant outcomes in peptide therapy come from combining peptides that target complementary biological pathways creating synergistic effects that exceed what any single peptide achieves alone

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Por encima de 3 g/da, los beneficios adicionales son marginales y el riesgo de efectos digestivos aumenta