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This is usually temporary as the digestive system adjusts

Digestion begins when you begin to chew and continues while the body is in a para-sympathetic (relaxed) state

Importantly, FIH studies also provide essential information for the design of Phase 2 trials , including decisions related to dosing schedules, administration frequency and safety monitoring strategies

Furthermore, under Fe-deficient conditions, PRs assist in acquiring iron (Fe) by generating siderophores, which are low molecular weight organic molecules ( Tables 1 , 2 )

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Planta Med 1998;64(4):353356