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Tenofovir Alafenamide (TAF): Tenofovir resistance substitutions, K65R and K70E, result in reduced susceptibility to abacavir, didanosine, emtricitabine, lamivudine, and tenofovir

Although the pharmacology of VPA is still not understood completely, the drug seems to enhance activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), impair activity of the excitatory neurotransmitter glutamate, and block sodium channels

Am J Obstet Gynecol (1986) 155:110913

More research, particularly on ALCAR, is needed to understand the practical significance of this effect