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Mitochondrial Ca 2+ overload due to MCU overactivation increases Ca 2+ sensitivity, enhancing myosin light chain phosphorylation and promoting contraction, and mitochondrial ROS activate redox-sensitive pathways such as MAPK and NF-B, driving VSMC proliferation and neointima formation

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Converting B6 from food to the active form, P5P: Vitamin B6 is the generic name for six different compounds, including inactive forms from foods, the type made by bacteria, and the converted forms used in cellular reactions

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Deletion of GPX4 in mice can lead to acute renal failure and ferroptosis

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less sensitive, more potent and a longer half-life

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Gut hormone PYY(3-36) physiologically inhibits food intake

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