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Mitochondrial Ca 2+ overload due to MCU overactivation increases Ca 2+ sensitivity, enhancing myosin light chain phosphorylation and promoting contraction, and mitochondrial ROS activate redox-sensitive pathways such as MAPK and NF-B, driving VSMC proliferation and neointima formation

Converting B6 from food to the active form, P5P: Vitamin B6 is the generic name for six different compounds, including inactive forms from foods, the type made by bacteria, and the converted forms used in cellular reactions

Deletion of GPX4 in mice can lead to acute renal failure and ferroptosis

less sensitive, more potent and a longer half-life

Gut hormone PYY(3-36) physiologically inhibits food intake
