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This mechanism means that any drug interaction involving an efflux transporter of glucuronides can have a direct impact on the systemic levels of the glucuronides, which in turn could change the levels of their corresponding aglycone due to the presence of glucuronidases

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For example, gliotoxin tends to accumulate in sinus cavities and is often associated with chronic sinus issues, whereas zearalenone acts as an endocrine disruptor typically seen in patients with fertility challenges or irregular menstruation cycles