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Importantly, pharmacological blockade of MARS1 with Nacetylcysteine effectively attenuated endothelial senescence and rescued erectile function, highlighting the therapeutic promise of targeting homocysteine sensing for treating age-exacerbated ED in HHcy populations

[DOI] [PubMed] [Google Scholar] Schrder C.H., Edefonti A., Fischbach M., Klaus G., Rnnholm K., Schaefer F., Simkova E., Stefanidis D., Strazdins V., Vande Walle J., Watson A., Zurowska A

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The observation that mice with genetically induced increases in intestinal permeability develop anxiety-like behaviours, hyporesponsiveness to rectal distension and activation of neurons within the thalamus, hypothalamus and hippocampus 31 demonstrates that increased intestinal permeability can effect changes in behaviour, visceral sensation and neurological activity