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A typical growing process is divided into two stages: a first stage in which the cells are cultured in complete anaerobic conditions, and a second stagetypically after 7296 h of cultivationin which soft oxygenation is generated by agitation to create the microaeration necessary for the formation of DMBI and cobalamin (Mauerhofer et al., 2019)

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Parenteral (intramuscular) administration of vitamin B12 completely reverses the megaloblastic anemia and GI symptoms of vitamin B12 deficiency

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