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The DAA Rep/SCO must ensure that written concurrence for the controlled interface is obtained from data owners and affected DAAs prior to permitting implementation of the connection

In this Review, we focus on advances in our understanding of inhibition of the HGF/c-MET pathway in patients with gastro-intestinal cancers, the prominent challenges facing the clinical translation and implementation of agents targeting HGF/c-MET, and discuss the various efforts, and associated obstacles to the discovery and validation of biomarkers that will enable patient stratification in this context

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