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Vitamin B12 Vitamin B12 is an essential nutrient the body needs to function properly

Drug treatment Sapropterin dihydrochloride The rationale for supplementation of sapropterin dihydrochloride, a synthetic tetrahydrobiopterin analogue, is based upon the defective biosynthesis or recycling of this essential cofactor for the aromatic L-amino acid hydroxylases in all types of BH 4 Ds

Despite a relatively short half-life of approximately 30 minutes, the peptide triggers gene expression changes that persist and cascade independently of its continued presence

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J Pathol 257: 198217, 2022

Since the net charge of CAND is -0.2, resulting in an overall neutral charge, it is difficult for CAND to be effectively transported to the cell nucleus on its own