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While GAG alone promote sprouting, they downregulate VEGF165-mediated signaling and, thereby, elicit VEGF165-independent and -dependent effects

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Here, through a proteomic screen of serum from AQP4-IgG-positive NMOSD patients and a control cohort, we observed a significant downregulation of Insulin-like growth factor 2 (IGF-2) in the serum of AQP4-IgG-positive NMOSD patients and correlated with disease severity

It engages in synthesizing selenoproteins, which are essential for antioxidant defense and regulating thyroid hormone levels

It has two forms: one is in an oxidized state, and the other is in a reduced state