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Dermatol 2009: 1:115119

However, these biomarkers have not been formally validated as specific proxies for CNS inflammation in COPD, underscoring the need for integrated biomarker neuroimaging studies (Table 2)

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Increased expression of ORMDL3 may contribute to the development of paucigranulocytic asthma, which is a significant subtype of non-T2 asthma, by inducing the upregulation of mediators involved in airway remodelling rather than inflammation [60]