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Another protease, ALV003, is further along in development and appears to have greater therapeutic potential

Manipulating CSE and ETHE1 levels in both directions, we found a consistent pattern in that the two enzymes mirrored each other: silencing CSE yielded the same effect (slower radical removal) as overexpressing ETHE1, and overexpressing CSE yielded the same effect (faster radical removal) as silencing ETHE1 (Fig