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Combinations of cytokines can also induce toxicity indirectly via astrocytes, for instance, IL-1, TNF- and C1q induce a neurotoxic astrocyte phenotype [242]

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p53 promotes CDKN1A gene transcription (coding for p21), which is known for regulating the cell cycle (134,135)

Abstract Caspase-independent cell death (CICD) has recently become a very important mechanism in lung cancer, in particular, to overcome a critical failure in apoptotic cell death that is common to disease progression and treatment failures

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10.1111/apt.14449 [DOI] [PubMed] [Google Scholar] 57