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[2] [5] High doses of acetaminophen are known to deplete endogenous glutathione stores, particularly in the liver, which may increase the risk of toxicity

Excessive ER-H 2 O 2 in the ER is prevented by the activities of various antioxidant enzymes, such as GPXs (isoform 7 and 8) and PRX4 29

doi: 10.1016/j.cmet.2010.11.008