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Bmal1 KO adipocytes display a distinct pattern via downregulation of circadian rhythm, insulin signalling, glycerolipid metabolism and glutathione metabolism, with upregulation of thermogenesis, autophagy and cAMP signalling (Extended Data Fig

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Thanks to their expanded interface with the target protein, peptide PROTACs demonstrate superior potency, higher selectivity, and reduced toxicity compared to low molecular weight compounds, especially when targeting proteins lacking well-defined binding pockets (Kargbo, 2019)

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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

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