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This finding is in accordance with the reported specificity for the L -enantiomer of the subsequent LhgO-catalysed reaction 8

The functions of the ascorbateglutathione cycle are powered by the pools of pyridine nucleotides, NAD(H) and NADP(H), as is ROS production by respiratory burst oxidase homologues (RBOHs) and other ROS-producing enzymes

First-line treatment involves high-intensity statins , which competitively inhibit the rate-limiting enzyme in hepatic cholesterol synthesis

The enzymes which have participated in these essential detoxification mechanisms comprise catalase, monodehydroascorbate reductase, superoxide dismutase, ascorbate peroxidase, glutathione reductase, dehydroascorbate reductase, guaiacol peroxidase [151]

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