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0791538 Kokomo IN McCreary, Waiter L

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Na H, et al

The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14

Consistent with the modular organization, MS/MS fragmentation of lipid precursors produces signature ions specific for each structural module and their grouping defines the lipid classes and individual species 2,6