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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

It also aids in breaking down fats and proteins

Slow gastric emptying, keeping the stomach full for longer

Though causation has not been established between vitamin B12 deficiency and depression, it has been found to be involved with many neurochemical pathways that potentially lead to this mental health disorder

For example, a study published in the American Journal of Clinical Nutrition found that B12 supplements reduced homocysteine levels and improved heart health in older adults

The severity of the rash tends to reflect how much of the vitamins you have in your system